- Promos for The Muppets featured the Muppets with cast members Tracee Ellis Ross and Anthony Anderson referencing their show. Ross and Anderson quiz Rowlf the Dog on all the places his show will follow him, including their dressing room and bathroom. Realizing his situation, Rowlf asks the pair if their show is safe from prowling cameras, and asks them if they need a dog.
- "Orange-is is the New Black-ish" is one of several shows that Fozzie Bear pitches to Scooter in the Muppets Now episode "Fever Pitch".
- In the episode "Rich Youngsta," Dre does a commercial for a rapper, Rich Youngsta that he shows to his agent, he then tells Dre he talked to him about more sponsorships, and even a guest spot on Sesame Street, Dre responds "With Elmo?" to which Rich Youngsta responds "with all of those furry fuzzy motherfuckers, man"
- In the episode "Inheritance," Rhonda forbids her brother Dre from eating in her car, when he questions if this is a rule, she replies "No, you just eat like Cookie Monster."
- Anthony Anderson plays Andre "Dre" Johnson Sr.
- Tyra Banks plays Gigi in "Plus Two isn't a Thing" and "Just Christmas, Baby"
- Chris Brown plays Rich Youngsta in "Rich Youngsta"
- Miles Brown plays Jack Johnson
- Daveed Diggs plays Johan Johnson (2016-)
- Laurence Fishburne plays Earl "Pops" Johnson
- Linda Mendoza directed seven episodes of the series, and four episodes of the spin-off Grown-ish
- Tracee Ellis Ross plays Dr. Rainbow "Bow" Johnson
- Nicole Sullivan plays Janine
- Raven-Symoné plays Rhonda Johnson as a recurring role
- Zendaya plays Resheida in "Daddy's Day"
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