Brushplant Cave is featured in the book Best Friends. While Mokey is painting an important picture of Red, her paintbrush falls apart. The only place where Mokey can obtain a Brushplant to replace her paintbrush is Brushplant Cave. Red and Mokey set out on a journey to the cave, traveling past The Cavern of the Creeping Crocus, The Great Gorge, and The Falling Rock Zone.
The cave is referenced again in the book Wembley and the Soggy Map when Wembley sees a sign on Mokey's cave reading that Mokey is visiting there.