CollegeHumor is a humor website launched in 1999 that produces original videos, series, and articles.
- In an animated parody called "Angry Birds PSA" released on February 22, 2011, Miss Piggy and Big Bird are among various fictional birds and pigs who decry the bird-on-pig violence of the Angry Birds video game. Piglet, Donald Duck, Daffy Duck, and Darkwing Duck also appear.
- "Pot Cookie Monster" from November 18, 2008, imagines a parody of Cookie Monster named "Pot Cookie Monster" and a little girl named Mackenzie counting to 5.
- "If Adult TV Shows Were Remade for Children" from July 28, 2011, imagines a kids' version of Mad Men titled Mad Men Babies, using a Muppet Babies-like font, a Nanny-like character, and a sign reading "Henson Cooper Nursery".
- "Muppet Teens" from July 23, 2012, imagines a sequel to Muppet Babies with rebellious, delinquent, and profane teenage Muppets.
- Utkarsh Ambudkar appeared as himself in "Hardly Working: Rap Battle" (2009)
- Jack Black appeared in CollegeHumor's Comedy Music Hall of Fame (2015)
- Rachel Bloom appeared in CollegeHumor's Comedy Music Hall of Fame (2015)
- Ryan Dillon voiced Porky Pig, Daffy Duck, and Tweety Bird in "Lebron Ditches Space Jam" (2011)
- Lin-Manuel Miranda appeared as himself in "Hardly Working: Rap Battle" (2009)
- Nitya Vidyasagar played Una in three episodes of CollegeHumor's web series Troopers (2019)
- "Weird Al" Yankovic appeared in CollegeHumor's Comedy Music Hall of Fame (2015)