Dexter's Laboratory is a Cartoon Network original series about a boy-genius who has a hidden, secret laboratory in his bedroom. Originating as shorts on the What a Cartoon! show, it became a full series that aired from 1996 through 2003.
- The Justice Friends segments feature a fictional television show called "Puppet Pals" which star Mitch and Clem, a Punch and Judy-esque puppet duo who visually resemble Ernie and Bert and stand behind a Sesame Street brick wall. Outside of Justice Friends, the Puppet Pals were also seen in live-action interstitials that have appeared in several episodes. They've also made cameos on The Powerpuff Girls, notably in the season one episode "Mommy Fearest."
- Christine Cavanaugh was the original voice of Dexter.
- Eddie Deezen voiced Mandark.
- Dom DeLuise voiced Koosalagoopagoop in several episodes.
- Rob Paulsen voiced Major Glory, Puppet Pal Mitch, and other characters.
- Frank Welker voiced Krunk, Monkey, and other characters.
- Paul Williams guest starred in the episode "Just an Old Fashioned Lab Song."