During a scene with E.T. and Gertie (played by Drew Barrymore), Sesame Street plays on the TV long enough for two sketches to appear. The first is an animated film about the letter B that aids E.T. in learning how to speak. The second scene features Big Bird introducing Grover in the courtyard as he demonstrates two chin-ups (this scene has been released commercially on Old School: Volume 1 as an insert for Episode 0536). The audio that ends the scene, however, was taken from Episode 1364 to provide a more appropriate dialogue for the film: Big Bird observes a rocket ship and remarks, "I think it came from outer space," just as E.T. begins to communicate his desire to phone home.
Sets featuring the children's bedrooms offer brief glimpses of Muppet toys: during a scene in which E.T. is reading a coloring book in the closet, a Bert toy can be seen hanging on the wall behind him; a toy closet between two bedrooms houses both a Scooterplush doll and an Animalpuppet.
The film's story was the basis for a comic spoof featured in the January 1983 issue. "E.C. the Extra-Celestial" featured Gonzo in the role of a visiting alien who takes up residence with the Muppets, creates a psychic bond with Kermit, watches Sesame Street with Annie Sue, and finds himself under the microscope of Muppet Labs.
E.T. makes an appearance in another comic book story published in the Summer 1983 issue. He doesn't speak or take part in the story, but appears to be a part of the crew of the Millenium Falcon from Star Wars.
When Gonzo and Ethan Hawke take off for the stars in a home-made spaceship fueled by oatmeal in the Fall 1985 issue, Camilla sends them off with a farewell sign that reads "Phone Home." Her message echoes a famous line from the 1982 film when E.T. communicates a desire to contact his people.
The Winter 1986 issue features a photo spread for an interview with Hollywood sound designer Mark Mangini. Dr. Bunsen Honeydew is pictured controlling a device created in Muppet Labs to create sound effects. Of the various parts labelled on the side is a phone with a sign that reads "Phone Home," another reference to a famous line from E.T.
In another 1984 episode, "From a Galaxy Far, Far Away...," the Babies find Irma, a strange creature who they assume is an alien, left behind on Earth. They attempt to contact the alien's family, and build a giant slingshot to send her home. The creature turns out to be a koala who escaped from the zoo. The basic plot is a similar take on the events of E.T. - The Extra Terrestrial -- save for the slingshot and the koala.