Edgar Allan Poe (1809-1849) was a writer of poetry and short stories, known primarily for their association with the macabre, and one of the founders of the detective story (his Auguste Dupin stories featured the first Watson figure). Some of his better known writings include The Raven, The Tell-Tale Heart, The Pit and the Pendulum, and The Fall of the House of Usher, among others.
- The seventh season Muppet Babies episode "Quoth the Weirdo" references a line from Poe's "The Raven" in the title. Baby Gonzo expresses interest in "that spooky once upon a midnight scary one," "The Raven" (uttering Nevermore). Gonzo tries to recite his own version, in the role of narrator.
- The Dog City episode "Comedy of Horrors" parodies Poe and his "The Tell-Tale Heart," reworked as "The Tell-Tale Heart, Liver, and Egg" by Edgar Al Poe. The story is presented on "His Master's Choice Theatre", narrated by Bugsy Vile, with Frisky in the lead role.
- Daws Butler played Toby Dammit in "Never Bet the Devil Your Head" on CBS Radio Workshop (1956, radio)
- James Mason narrated The Tell-Tale Heart (1953, animated short)
- Ian McShane played the prefect of police in The Murders in the Rue Morgue (1986, TV)
- Richard Mulligan played William Hopkins in "The Oblong Box" on CBS Radio Mystery Theater (1975)
- Ken Nordine read "The Conqueror Worm" on Closed On Account Of Rabies: Poems And Tales Of Edgar Allan Poe (1997, album)
- Vincent Price played Roderick Usher in House of Usher (1960 film), Nicholas Medina in The Pit and the Pendulum (1961), three different leads in Tales of Terror (1962 film), Dr. Erasmus Craven in the loosely inspired The Raven (1963 film), Prince Prospero in The Masque of the Red Death (1964 film), Verden Fell in The Tomb of Ligeia (1964 film), read four stories in An Evening with Edgar Allan Poe (1970, TV), and read "Ligeia" (1977 album)
- George C. Scott played Auguste Dupin in The Murders in the Rue Morgue (1986, TV)
- Frances Sternhagen played Margarita in "The Cast of Amontillado" on CBS Radio Mystery Theater (1975)
- Richard Vernon played Dr. Vivian in The Tomb of Ligeia (1964 film)
- Orson Welles performed "The Tell-Tale Heart" on The Mercury Summer Theater (1946, radio)
- Mak Wilson played the ape in The Murders in the Rue Morgue (1986, TV)