- In "Dr. Seuss vs William Shakespeare" and "Steven Spielberg vs Alfred Hitchcock", the word "Muppet" is mentioned.
- In "Sir Isaac Newton vs Bill Nye", Isaac calls Bill "Beaker in a bowtie".
- The Season 4 finale features a rap battle between Jim Henson (played by Nice Peter), accompanied with a Kermit the Frog puppet, and Stan Lee (EpicLLOYD), only for Walt Disney to butt in at the end.
- In "Gordon Ramsay vs Julia Child", Gordon calls Julia's show "One part Big Bird, two parts Miss Piggy"
- In "Bruce Banner vs. Bruce Jenner", Jenner, as Caitlyn, references Kermit's Lipton Tea meme and song "Bein' Green" in one lyric.
- Snoop Dogg played Moses in a battle against Santa Claus.
- Keegan-Michael Key played Gandhi and Michael Jordan in their battles against Peele's characters.
- Jordan Peele played Martin Luther King Jr. and Muhammad Ali in their battles against Key's characters.
- Arnold Schwarzenegger made an appearance near the end of Robocop vs. Terminator
- "Weird Al" Yankovic played Sir Issac Newton in a battle against Bill Nye.
- Lilly Singh portrayed Wonder Woman in a battle against Stevie Wonder.
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