Family Guy is a FOX animated sitcom aimed at a mature audience, revolving around a dysfunctional family known as the Griffins. Created by Seth MacFarlane, who had previously worked as an animator and writer for Hanna-Barbera, the series premiered in 1999.
Pop-culture references and satire are the norm of Family Guy, most of which usually occur during the show's signature cutaway vignettes. The Muppets are among the cultural figures that have been parodied and/or mentioned.
|Picture||Episode / Description|
|"I Never Met the Dead Man"|
In the cold opening, Lois sees Stewie out on the front lawn playing with his Sesame Street Phone (an electronic toy phone). Stewie talks to Ernie.
When Ernie asks Stewie if he can count to three, Stewie answers by shooting the phone with his ray gun three times, counting while he does so, until it catches flames. "Can I count to three? For god's sake, I'm already shooting at a fifth grade level!"
|"Mind Over Murder"|
Peter, under house arrest, complains to Lois that he can't watch TV anymore, as every show has been mashed in with one another. He watches the following program, Homicide: Life on Sesame Street, which the announcer warns, "contains adult content that is brought to you by the letter H."
In the episode, Bert, in the role of the hard, drunkard cop, with Ernie as his life partner – both seen naked in bed – is woken up by a phone call reporting an attack at Hooper's, at which point after getting up, he and Ernie get into a quarrel with each other for the former drinking, and the latter eating cookies in bed. Ernie gets the best out of Bert, the scene ending with Bert frowning at himself and letting out a heavy sigh, accompanied by a comedic music tag.
|"I Am Peter, Hear Me Roar"|
A catfight between Lois and Gloria Ironbachs occurs at a women's charity dinner. At one point during the fight, a baker walks out of the kitchen, calling out – while carrying – "Ten banana cream pies!" before getting run over by the two ladies, spilling his pies everywhere.
|"A Picture is Worth 1,000 Bucks"|
At a skating rink in Central Park, Meg attracts a pigeon with her birdcalls. Peter is impressed, and asks her to do it again. She does, only this time, a pigeon doesn't respond. Instead, after a brief moment of silence, an aggravated Big Bird shows up to chew Meg out, complaining about how much of a hassle it is for him to get around town.
|"Brian Does Hollywood"|
Stewie "plays" Interrogation with dolls of Kermit the Frog, as the captive, for thwarting Stewie's world domination plans, and Miss Piggy, as the captive's girlfriend, whom Stewie proceeds to get "tender" with in order to coerce an answer from the frog.
A clip of Stewie and the Miss Piggy doll from this scene appears in a montage of clips during the musical number, "The Freakin' FCC" in the episode “PTV."
|Family Guy Viewer Mail #1|
In the second segment, "Super Griffins," Peter and Brian are watching a clip of Sesame Street on TV, involving The Count counting bats in his castle. Peter questions to Brian about The Count's (obvious) physical appearance, inquiring if there had ever been an episode [of Sesame Street] in which The Count "kills somebody and sucks on their blood for sustenance." Brian points out that no such episode exists.
While staying at Cleveland's house, Peter brings over prostitutes. He shows Cleveland, in another reference to the Number Song Series, seven prostitutes as they are being counted by a children's chorus from off-screen.
Stewie, as a CashScam executive, gets a call on his Sesame Street Phone from Grover, regarding the letter G and the number 6. Grover (whose voice is not heard) can’t seem to control himself, so Stewie has him call back later. After the conversation, Stewie asks Brian to send Lois a congratulatory basket, and to tell Cookie Monster, if he calls, that he won’t talk to him until he gets out of rehab.
In a cutaway vignette, Cookie Monster is seen in a rehabilitation clinic, being treated for his cookie addiction. Doctors enter the room for inspection, during which one of them finds a plate of cookies hidden under his bedsheets. Cookie tries to deny any knowledge of this, but immediately goes on a binge, at which point the doctors tackle Cookie and inject him to sleep.
Cookie appears again later on in the episode, hiding in a stall in the women's restroom, where Lois walks in on him free-basing a spoonful of cookie dough.
Peter laments about his new job at the Pawtucket Brewery, where he is constantly being ordered around --- a position similar to that of his last job as Dr. Bunsen Honeydew's lab assistant. In a cutaway flashback, "Beaker" meeps, and Bunsen responds, "Agreed, Peter."
|"The Father, the Son, and the Holy Fonz"|
Stewie has been confined to a plastic ball after having been infected with contaminated holy water. At one point, he finds Peter and Lois outside the Church of The Fonz, and tells them, "You would not believe the morning I had." This leads to a flashback showing Stewie's experience as the "pinball" in the Pinball Number Count intro.
The entire sequence is animated exactly the same as the original, frame-to-frame and with the original audio intact.
In a reference to All the Presidents Men – a 1976 film chronicling the real-life investigations of the Watergate scandal – Brian, accompanied by Stewie, drives up to a multi-story car-park at night, to meet with a source who will help him expose Mayor Adam West's corrupt ways. Brian and Stewie meet the informant, who turns out to be (unbeknownst to them) Kermit, going by the pseudonym Deep Throat and seen standing in the dark. Kermit wishes to remain anonymous as he gives information, but his cover is blown when Brian begins to get a good idea of whom he was just talking to. Kermit exits in a manner similar to his Muppet Show introductions, at which point a confused Stewie turns to Brian and asks, "What's his appeal?"
Frank Welker voiced Kermit in this scene.
A distraught Carter Pewterschmidt (Lois' father) tells Peter and Lois that his wife Barbara had just left him for Ted Turner, and begins to worry about what the two could be doing at this minute (he assumes it to be sexual activity). As Carter speaks, Barbara is...giving Ted toys of Elmo, Telly and Ernie to play with in the bath. But Ted doesn't want Ernie because "Ernie doesn't like the monsters!"
When Peter decides to build a home movie theater, Lois hopes that it would be better than the living room balcony he built last time, which, as revealed in a flashback, happened to be Statler and Waldorf's box. The two curmudgeons comment on that night's episode of Lost.
|"Stewie Loves Lois"|
Peter is under the assumption that he has been sexually harassed by Dr. Hartman – the threat in question being a required prostate exam for prevention of cancer – and decides to sue. "Too many people get away with injustice, like the folks you meet in those Louisiana swamps." In the following vignette, alluding to the first scene in The Muppet Movie – in a rather discriminatory manner – Kermit sits on a log in said swamp, playing his banjo when a lost tourist asks him for directions to town. Kermit answers, "It's back the way you came," at which point he takes out his shotgun.
Lois, Meg and Chris watch "Round Table," with panelists Al Michaels, Harold Ramis, Ray Romano, and Kermit, all of whom seem to get their voices mixed up with one another.
|"The Tan Aquatic with Steve Zissou"|
At the hospital, Brian reassures Stewie that the mole on his stomach, which they believe could be connected with cancer, might turn out to be harmless until Dr. Hartman confirms otherwise, so they will have to wait for results (which will take a few days, according to Hartman). Stewie reminds Brian, "Jim Henson had a 'wait-and-see' attitude, and look what happened to him. Now we’ve got wrong-sounding Muppets!"
The following vignette shows Kermit and The Swedish Chef backstage at The Muppet Theatre, both with very different voices - Kermit with a slow, monotonous voice, and the Chef speaking in English. The "American Chef" offers to make spaghetti for Kermit, to which Kermit lets out a drawn-out "Yay..." while slowly waving his arms.
The two appear again at the end of the episode, commenting on Peter and Chris' reconciliation. Another "wrong-sounding" Muppet shows up and that ends up being Fozzie Bear (voiced here by Michael Clarke Duncan) who asks in a deep voice, "Wocka wocka, who wants to hear a funny-ass joke?"
|"Believe it or Not, Joe's Walking on Air"|
Using computer graphics, Dr. Hartman shows Joe what he'd look like with legs from a variety of donors, including Big Bird.
|"Baby Not on Board"|
The Griffins are stuck in a train station, trying to get back home to Stewie, whom they realized they've left behind while on vacation. When Brian finds a pick-up truck that will take them to Quahog, Peter suggests, "Let's all leave before Stewie gets hurt, like Fozzie Bear when he went to Saudi Arabia." In a cutaway vignette, Fozzie performs a monologue for a crowd of Saudi Arabians. "It's good to worship Allah, because I used to worship Some-ah! Wocka wocka!" Fozzie then moves on with the next joke. "I once knew a guy who was so Arab..." One of the Arabs interjects, asking Fozzie in a threatening manner, while wielding a sword, "How Arab was he?!" Fozzie backs down and nervously replies, "Uh, he was so Arab...that everybody liked him, and there was nothing funny about him at all." This was a modification to the joke from The Muppet Movie in the El Sleezo Cafe that had to do with a fat sailor.
|"Not All Dogs Go to Heaven"|
At the end of the episode, and throughout the credits, it is revealed that the entire Family Guy universe exists in the lamp in Adam West and Rob Lowe's bedroom. The set is modeled after Ernie and Bert's bedroom.
|"Family Guy Presents: Seth & Alex's Almost Live Comedy Show"|
Seth MacFarlane and Alex Borstein introduce a batch of lost screen tests featuring well-known Hollywood actors – all of whom are portrayed by Seth and Alex in these screen tests – auditioning for odd, rather out-of-norm roles in different films (had they actually been cast, these films would have failed miserably, as evident by the actors' inability to stay focused during takes). These include Bea Arthur in Showgirls, Gregory Peck in Transformers, Kathy Griffin in The Piano, The Cowardly Lion in United 93, Renée Zellweger in Independence Day, and Kermit (a commercially licensed hand puppet) who auditions for Tom Hanks' role in Philadelphia.
The director, heard from off-screen, tells Kermit that he might be perfect for the role, adding (about Kermit's performance), "That was the gayest thing I've ever seen!" Kermit frowns at the camera, shaking his head in contempt.
|Jerome is the New Black|
At the Drunken Clam, Peter, Joe, and Quagmire all miss Cleveland, who has left Quahog to star in his own spin-off series. Peter suggests that they find a replacement to fill in the void, which he compares to Statler without Waldorf, as represented in the following vignette. It turns out that, without the latter, the former finds it much easier to enjoy the show.
|The Hand That Rocks the Wheelchair|
In the DVD cut of the episode, Statler and Waldorf observe that Meg finally has some lines. Waldorf pushes for a second joke from her, to which Statler tells him the first one was enough.
|"Something, Something, Something, Dark Side"|
In an episode-length parody of The Empire Strikes Back, Chris, as Luke Skywalker, lands on Hoth, where he is warned by Peter, as Han Solo, of snow monsters. Chris dismisses this, but one does show up in front of him – a gargantuan Cookie Monster with horns, playing the role of the Wampa – yelling "COOKIE!" and knocking Chris out unconscious.
Chris later wakes up to find himself in a cave and attempts to escape, only to see the same monster coming for him again. Chris fends off the monster using his lightsaber, eventually cutting its arm off, at which point Chris realizes the beast is harmless. "Me was going to ask you to snow monster ball, but now forget it!" The monster then runs away in tears.
|"Go, Stewie, Go!"|
Stewie shows Brian an episode of the American adaptation of British children's program Jolly Farm, in which Stewie landed a role on while posing as a girl named Karina Smirnoff. The proceeding clip shows Stewie (as Karina) and his co-star Julie on a mock Sesame Street – out of context with Jolly Farm, hence its title; also not the actual setting of said show – with two actors dressed as Big Bird and Oscar the Grouch, both of whom are being passed off in the clip as "Large Bird" and "Moody Green Garbage Creature" (though the exchanges made after their introduction give them away). Stewie (again, as Karina) berates the latter for his bad temper, calling on butch duo "Bernie and Gert" to deal with him.
|"April in Quahog"|
Peter tells Brian that he once stuffed the ballot box for the Oscars, cutting away to a scene from the ceremony, where Grover is one of the nominees for Best Actor in a Leading Role, along with Bluto from Popeye, a red guy, a boob, and Daniel Day Lewis. All nominees lose to the red guy.
|"Partial Terms of Endearment"|
Lois points out that Meg has never had a boyfriend for more than a few weeks. Meg recalls the time she dated The Count, who counted three nipples on her and quickly left.
|"And I'm Joyce Kinney"|
Lois tells Joyce Kinney that she's a big time celebrity just like Miss Piggy. A scene follows depicting Fozzie in a Pigs in Space costume asking why "Bears in Space" has been canceled. Kermit, who has been visibly beat up, replies that there's been a change.
Lois and Bonnie decide to do some "Muppet-style sightseeing" while in Paris, complete with puppet versions of themselves.
|"Back to the Pilot"|
Stewie has dolls of Bert and Ernie in his room. When Brian sees that he has the Ernie doll tucked under a box, Stewie says that Ernie is getting a cat-scan. Later in the episode, Stewie ponders if Brian changing the past may have resulted in Cookie Monster inventing Cookiebook instead of Facebook.
Statler & Waldorf are at Ford's Theatre during the assassination of Abraham Lincoln. When Statler cracks a joke, he is also shot in the head.
Stewie recalls being the human resource director for The Muppets, which leads to a cutaway gag of him firing Beaker due to him swiping ingredients from the Muppet lab to make meth, which is revealed he had sold to Big Bird, who appears looking beat-up, stoned and with feathers missing.
|"In Harmony's Way"|
At the start, the family is watching TV, and the announcer says, "We now return to Muppet Babies." On the screen, the adult Kermit the Frog and Miss Piggy are looking into a crib, and Kermit notices that "Kermie Junior" isn't doing very well. It then pans down to a very ugly half-frog/half-pig mutant, complaining that he is in constant pain and just wants to be killed.
|"Herpe the Love Sore"|
Peter and Lois watch VH1's Behind the Music featuring The Electric Mayhem. Set after Animal has found God and cleaned up his act, Dr. Teeth describes Animal's addiction to felt and Janice alludes to an implied rough anal sex encounter. Animal has no memory of the incident but does not doubt that it took place. All three characters are voiced by Seth MacFarlane.
Stewie has faced bigger challenges than breaking up Peter and Lois, like riding a bike in The Muppet Movie. He then states, "This is amazing to everyone in the '70s."
|"A Lot Going on Upstairs"|
Stewie uses the power of his dreams to transform himself into Elmo, noting that he speaks bad English on an educational show.
Cookie Monster is the bank manager who immediately approves of the loan for Peter and Lois' cookie store. When the shop is closed, Cookie Monster happily takes back the loan in exchange for the store.
|"The Boys in the Band"|
When Brian tries to point out to Stewie that it isn't easy to work with an ex, a cutaway gag shows Scooter asking Miss Piggy about calling in sick the previous day. As she brushes it off with humor about having a "frog in her throat" while giving Kermit the Frog a poke in the ribs, he tiredly suggests she quit drinking.
|"Inside Family Guy"|
During a "behind-the-scenes" tour hosted by James Woods of the production offices of Family Guy, props from past episodes, including a cartoon version of Muppet Lois from "Foreign Affairs," can be seen. In the same episode, Peter gives Chris a t-shirt with "hip-hop Kermit" on it to celebrate returning to the show.
|"The Peter Principal"|
Peter and Lois watch Sesame Street after its move to HBO, with the show featuring adult content, in which Cookie Monster "eats" at Big Bird's rear, parodying a scene from the HBO series Girls.
|"The D in Apartment 23"|
Stewie decides to go along to the Quahog University library to avoid having to do sad, one-woman shows like Meg in his future, leading to a cutaway gag of Meg singing "I Love Trash" while dressed as Oscar the Grouch. When Peter questions whose genes she received, Lois points out that he is wearing a garbage bag as a cape. They are both quieted by Oscar who notes that Meg is doing an excellent job in the role.
|"The Woof of Wall Street"|
Cookie Monster, Elmo and Herry Monster take offense at Brian being called a monster for investing in a company that makes protein shakes from dogs. When Elmo points out that some monsters are nice, Brian retorts with his performer's sexual abuse accusation, to which Elmo responds by noting that the accuser recanted the charge. When Stewie notes that a second case expired due to the statute of limitations, Elmo refuses to comment. After an uncomfortable pause, Cookie Monster shouts "Cookie!" which elicits joy from Brian and Stewie.
|"No Giggity, No Doubt"|
When a disabled student named 'Kermit Legs' Kyle is named King of the James Woods High School prom, another student with a Kermit head is disappointed after thinking he was close to winning.
Peter accuses Lois of using his Elmo toothbrush. Distracted by Connie D'Amico's bullying, Lois concedes she may have. Shortly after, Peter reports her to the police.
|"Rich Old Stewie"|
As an elderly Seamus has been kept on hold for years for Spirit Airlines in a distant future, Scooter steps into his room to announce that it's almost time to go onstage. Seamus is torn between wanting to fly to Pittsburgh and hosting The Muppet Show.
An ESPN 30 for 30 episode suggests that Oscar the Grouch was the mastermind behind the Houston Astros cheating scandal, during which pitching signals were stolen and signaled by beating on trash cans.
|"Boy's Best Friend"|
Peter, Cleveland and Quagmire take Joe's classic car for a drive and crash into a pile of trash cans, killing Oscar the Grouch in the process. Before he dies, Oscar requests Peter tell his ex-wife to 'go **** herself'.
|Picture||Intended Episode / Description|
|"Peter's Got Woods"|
|"The Perfect Castaway"|
During a family budget crunch, Stewie complains that his Oscar the Grouch diapers have been replaced with José the Grump.
|"Grumpy Old Man"|
Statler and Waldorf are in a nursing home that is being toured by Carter Pewterschmidt and the Griffins. Waldorf complains of always being constipated due to a hand up his posterior.
Tom Tucker's twin brother Tim, a Washington D.C. news reporter, has the story of a emu donated to the National Zoo from Emo Phillips and Brian Eno that was named after a popular Sesame Street character, making him Emo Eno Elmo Emu.
- "Peter, Peter, Caviar Eater" - In an attempt to raise money to buy back the Griffins’ house in Quahog, Peter tries to convince a couple of investors that the Pewterschmidt mansion has historic value by passing off random, ordinary objects as proof. The investors are unimpressed and leave the room, at which point Peter urges them to come back to see the rock he is holding in his hand, which he explains, is "where the pilgrims landed on Fraggle Rock!"
- "A Picture is Worth 1,000 Bucks" - Earlier on in the episode, before Meg and Peter's rather awkward encounter with Big Bird, the Griffins check into the Plaza Hotel, where Peter asks the receptionist, "Do you guys have bellhops that are rats, like the Muppets?"
- "Fifteen Minutes of Shame" - Peter tries to get attention on the Griffins' reality show with a puppet (Wayland Flowers' Madame) when the camera starts to pan away from Peter to something more interesting. Peter wants the cameraman to come back because "she's gonna sing 'Rainbow Connection'!"
- "Let's Go to the Hop" - Quahog 5 news anchors Tom Tucker and Diane Simmons report on a drug craze called Toad (licking toads). Tucker points out other names for the drug: “Lillipadding," “Frenching the Prince," and "Doing Kermit."
- "A Fish Out of Water" - A tough biker wants Jim, the con-man posing as a tattoo artist, to draw a skull on his thigh, but Jim suggests Kermit the Frog. The biker says he just wants a skull, but Jim goes ahead with drawing Kermit.
- "Ready, Willing, and Disabled" - In an attempt to outdo Joe, Peter, posing as a handicap, meets with Tom Tucker in his office at the Quahog 5 TV station, demanding, among other things, his own telefilm starring Valerie Bertandernie (his mispronunciation of actress Valerie Bertinelli's name).
- "Saving Private Brian" - Brian and Stewie have joined the army (much against the former's will), where at one point they hear from the announcer that their platoon will be shipped out to Iraq. Brian distressedly exclaims "Iraq!?!" to which Stewie assures him, "He probably meant 'Fraggli-Roc'".
- "Stewie Kills Lois" - After Stewie begins admiring the echoing of his inner monologue, his thoughts echo Pigs in Space in the style of the sketch's opening narration.
- "Blue Harvest" - Brian, during his introduction scene of playing Chewbacca in a spoof of Star Wars Episode IV: A New Hope, mimics Chewbacca's trademark gargling before spitting in a sink and then saying, "Always gargle before a take-off. Wocka-wocka!"
- "Long John Peter" - In the Animatic of the episode from DVD Volume 7 Peter mentions Big Bird & Radar in a deleted version of the opening used in the animatic.
- "And Then There Were Fewer" - At a dinner party, Carl asks Tom Tucker if he'd ever seen "Jim Henson's Labyrinth."
- "Road to the North Pole" - After Stewie is told that Santa Claus isn't real, he sarcastically asks if Elmo isn't real also.
- "It's a Trap!" - When the Ewoks blow their bugles to signal a battle, one of them blows a horn instead, and a chicken flies out of it. This references The Muppet Show's Great Gonzo's attempts to blow his horn at the end of the opening theme. Also, an early script for this Star Wars spoof was called "Episode VI: The Great Muppet Caper," but it was thought to be too confusing for people who might be trying to buy the actual The Great Muppet Caper.
- "Be Careful What You Fish For" - Billy Finn asks a question about Peter's penis and observing it, wondering if it's like Mr. Snuffleupagus.
- "The Old Man and the Big C"- When Quagmire wants to throw away his wrapper and the librarian says no, he states "Well, it's not easy Being Green."
- "Valentine's Day in Quahog" - When Stewie visits the '60s to find out what love was like he tells a young Lois (who he doesn't find out until later) about Sesame Street, which he says will "blow her mind".
- "This Little Piggy" - When Meg comes downstairs, Peter realizes Meg was upstairs the whole time, previously thinking the clomping sounds were coming from Junior Gorg.
- "Carter and Tricia" - When he is told of a visit by a reporter, Carter Pewterschmidt inquires if it is Kermit in a trench coat, believing that to be the definitive proof of being a reporter.
- "Dearly Deported" - While searching for something to watch with Chris' girlfriend Isabella's children, Stewie briefly considers Muppet Babies.
- "Dog Bites Bear" - Peter visits the grocery store using the Sesame Street cartoon "I Can Remember" to help him with his list. However, he gets the list mixed up.
- "Veteran Guy" - While at a thrift store, Peter compares an Aiwa double tape deck to Statler & Waldorf and it proceeds to joke about the selection as well as the customers stinking. After laughing at this, Peter deadpans to the camera that Jim Henson died of treatable pneumonia. When the Peter and his friends are kicked off of a Southwest Airlines flight when they get caught pretending to be veterans, a set of overhead bins also imitate Statler and Waldorf, joking about being 'gay' because they have 'bags' in their mouths.
- "You Can't Handle the Booth!" - During the recording of a DVD commentary within the episode, Peter sings "Halfway Down the Stairs" when his head gets caught in the star railings, much to Lois' annoyance as a time filler. When their house is robbed later in the episode, the burglars sing the song again and the family is much more receptive, Peter's rendition of the song can later be heard in the non-commentary version of the fictional episode in the Season 17 DVD.
- "Throw it Away" - When Lois kicks Peter out of the house, Peter is offended that she would kick him out of the house that he pays for. Then Peter reveals that Lois’ parents paid for the house while Chris puts a pretend mortgage coupon into Stewie’s Sesame Street mailbox.
- "Yacht Rocky" - After Peter learns that an employee has to be fired from the brewery due to budget cuts, he stumbles over his boss' name by referring to him as Ernie and Cookie Monster before correctly identifying him as Bert.
- "The Marrying Kind" - After watching "The Muppet Show" with Stewie, Peter finds himself leading a large part of the Family Guy cast in singing "The Muppet Show Theme". The song is also involved in an Inception scene of Peter's.
- "Customer of the Week" - Stewie, showing signs of pinkeye, discovers he plays "Elmo's ABC's" on the same towel used by the family to sit on.
- "Meg Goes to College" - Peter has Meg read a letter of recommendation to Brown University that he wrote from Big Bird in his voice, during which he questions why you never see Grover and Super Grover at the same time, as well as mentioning Ryan Reynolds' appearance on Sesame Street.
- "Family Cat" - Peter cites a "lack of Kermits" for his dislike for HGTV home shows.
- In The Muppets, the show is spoofed as Number One Dad on the CDE prime time schedule for Fox on Sunday at 9pm (Family Guy’s broadcast slot at the time).
- Paula Abdul re-recorded her lines in a rehashed version of the music video of her song “Opposites Attract” in the episode "The Father, the Son, and the Holy Fonz" and voiced herself in "Lois Kills Stewie"
- Jason Alexander appeared on the CD Family Guy Live in Las Vegas
- Ed Asner provided a voice in the episode "One if by Clam, Two if by Sea"
- Dan Aykroyd voiced himself in the episode "Spies Reminiscent of Us"
- Drew Barrymore voiced herself in Stewie Griffin: The Untold Story, Jillian Russell in various episodes, and Mrs. Lockhart in the episode "Fast Times at Buddy Cianci, Jr. High"
- Kristen Bell voided Martha in "Petey IV"
- Candice Bergen voiced Gloria Ironbachs in the episode "I Am Peter, Hear Me Roar", and reprised her role as the titular character of Murphy Brown in "A Picture is Worth 1,000 Bucks"
- Sandra Bernhard voiced herself in "Ratings Guy"
- Pat Crawford Brown voiced a Sanka dancer in the episode "Peter's Daughter"
- LeVar Burton voiced himself in the episode "Not All Dogs Go to Heaven"
- Sinbad voiced himself in "Tales of a Third Grade Nothing"
- Carol Channing voiced herself in the episode "Patriot Games"
- Lacey Chabert voiced Meg in the first season, a few episodes of season two, for one scene and line in "Yug Ylimaf", and as herself in "Griffin Winter Games"
- Chevy Chase reprised his role as Clark Griswold from the National Lampoon films in the episode "Blue Harvest" and voiced himself in the episode "Spies Reminiscent of Us"
- Tony Danza voiced himself in the episode "Ready, Willing, and Disabled"
- Phyllis Diller voiced Thelma Griffin in three episodes, "Mother Tucker", "Peter's Two Dads", and "Padre de Familia"
- Michael Dorn voiced Worf in the episode "Peter's Got Woods" and voiced as himself in the episode "Not All Dogs Go to Heaven"
- Robert Downey Jr. voiced Patrick Pewterschmidt in the episode "The Fat Guy Strangler"
- Charles Durning voiced Francis Griffin
- Erik Estrada reprised his role as Ponch from CHiPs in the episode "I Never Met the Dead Man"
- Jimmy Fallon appeared as himself, in live-action footage, in the episode "We Love You, Conrad"
- Dakota Fanning voiced a little girl in "To Love and Die in Dixie"
- Jamie Farr voiced himself in the episode "Believe It or Not, Joe's Walking on Air"
- Craig Ferguson appeared as himself, in live-action footage, in the episode "We Love You, Conrad"
- Harvey Fierstein voiced Tracy in the episode "The Former Life of Brian"
- Johnny Galecki played Leonard Hofstetter in the episode "Business Guy"
- Jennie Garth voiced Kelly Taylor in Family Guy Presents Stewie Griffin: The Untold Story
- Ricky Gervais played Billy Finn in "Be Careful What You Fish For"
- Gilbert Gottfried voiced himself through Peter's horse in the episode "Boys Do Cry"
- Seth Green provides the voices for Chris Griffin, Neil Goldman, and other characters
- Mark Hamill voiced Luke Skywalker in the episode "When You Wish Upon a Weinstein"
- Kadeem Hardison voiced an NBA player in "Ratings Guy"
- Neil Patrick Harris voiced Barney Stinson in the episodes "No Chris Left Behind" and "Peter's Progress"
- Anne Hathaway voiced Mother Maggie in the episode "Go, Stewie, Go!" and as herself in "April in Quahog"
- Sherman Hemsley voiced himself in the episode "The Father, the Son, and the Holy Fonz"
- Tom Hollander voiced James Corden in the episode "Disney's The Reboot" and was heard in two other episodes
- Randy Jackson voiced himself in the episode "Lois Kills Stewie"
- Allison Janney voiced the editor of Teen People in the episode "Dial Meg for Murder"
- Waylon Jennings provided narration in the episodes "Chitty Chitty Death Bang" and "To Love and Die in Dixie"
- Carol Kane voiced Carol in the episode "Emission Impossible"
- Anna Kendrick voiced Nora in the episode "Internal Affairs"
- Jimmy Kimmel voiced Death's dog in the episode "Mr. Saturday Knight"
- Mila Kunis voices Meg Griffin
- Hugh Laurie voiced a bar patron in the episode "One If by Clam, Two If by Sea" and House in the episode "Business Guy"
- Cloris Leachman voiced herself in the episode "Petarded"
- Jay Leno appeared as himself in live-action footage in the episode "We Love You, Conrad"
- Ray Liotta voiced Zack in the episode "Brian Does Hollywood"
- Jane Lynch voiced Dotty Campbell in the episodes "From Method to Madness" and "Road to Europe"
- Marlee Matlin voices Stella and appeared as herself in "Family Guy Presents: Seth & Alex's Almost Live Comedy Show"
- Gates McFadden voiced herself in the episode "Not All Dogs Go to Heaven"
- Michael McKean voiced Pengrove Pig, Andy Rooney, and a camel salesman in the episode "Road to Europe"
- Kate McKinnon voiced Karen Griffin in three episodes
- Ed McMahon voiced himself in the episodes "Death Has a Shadow" and "When You Wish Upon a Weinstein"
- Kevin Michael Richardson voices various characters
- John Moschitta, Jr. voiced himself in "Fox-y Lady"
- Jason Mraz voiced Some Guy with a Hat in the episode "April in Quahog"
- Conan O'Brien voiced himself in the episode "Into Harmony's Way"
- John O'Hurley voiced the cult leader in the episode "Chitty Chitty Death Bang"
- Haley Joel Osment voiced several characters in the episodes "Dammit Janet!", "There's Something About Paulie", and "The Thin White Line"
- Jim Parsons voiced Sheldon Cooper in the episode "Business Guy" and a "Gay-Jacker" in "Joe's Revenge"
- Regis Philbin voiced himself in the episode "Family Guy Viewer Mail #1"
- Helen Reddy voiced herself in the episode "Blue Harvest"
- Kelly Ripa voiced herself in the episode "Family Guy Viewer Mail #1"
- Seth Rogen voiced Peter under the "Seth Rogen gene" in "Family Gay" and himself in "Fox-y Lady"
- Christy Carlson Romano voiced Quagmire's One-Night Stand in the episode "I Take Thee Quagmire"
- Amanda Seyfried voiced Ellie in "Boy (Dog) Meets Girl (Dog)"
- Jason Segel voiced Marshall Erickson in the episode "Peter's Progress"
- Florence Stanley voiced Thelma Griffin in the episode "Holy Crap"
- Ben Stein voiced Rabbi Goldberg in the episodes "When You Wish Upon a Weinstein" and "Family Goy"
- Patrick Stewart voiced several characters including himself in three episodes, Picard in "Peter's Got Woods" and "It's a Trap!", his American Dad! character Avery Bullock in "Stewie Kills Lois" and "Lois Kills Stewie", the inner voice of Susie Swanson, and others
- Ben Stiller voiced himself in the episode "No Meals on Wheels"
- Tara Strong provided the speaking voice of Eliza Pinchley in "One If by Clam, Two If by Sea" and Meg's singing voice in the episode "Don't Make Me Over".
- Nicole Sullivan voiced Muriel Goldman and voices several additional characters
- David Tennant voiced Tenth Doctor from Doctor Who in "Inside Family Guy"
- Jennifer Tilly voices Bonnie Swanson
- Alex Trebek voiced himself in the episode "I Take Thee Quagmire"
- Neil deGrasse Tyson served as Science Consultant on "The Big Bang Theory"
- Leslie Uggams voiced herself in the episode "Mind Over Murder"
- Patrick Warburton voices Joe Swanson and appeared as Cal Johnson in Family Guy Presents: Seth & Alex's Almost Live Comedy Show
- Frank Welker voiced many characters including Fred from Scooby-Doo in "I Never Met the Dead Man" and "Deep Throats" (in a deleted scene) and Megatron from Transformers in "Ocean's Three and a Half"
- George Wendt voices Norm Peterson in the episode "Road to Rupert" and himself in "Three Kings"
- Wil Wheaton voiced himself in the episode "Not All Dogs Go to Heaven"
- Betty White voiced herself in the episode "Peterotica"
- Fred Willard voiced Dave Campbell in the episodes "From Method to Madness" and "Road to Europe"
- starwarsblog.starwars.com "Comic-Con 2009: Family Guy Spoof Empire" August 3, 2009 by Bonnie Burton