Game of Thrones is an HBO TV series (premiering in 2011) based on the Song of Ice and Fire book series by George R.R. Martin.
- Elmo appeared in a 2019 Game of Thrones-themed video with Cersei (Lena Headey) and Tyrion (Peter Dinklage) for Sesame Street's Respect Brings Us Together. Caricature Muppets of Cersei and Tyrion appear in another video for the campaign, where they are briefly seen knocking on Oscar's trash can.
- Sesame Street spoofed the series as "Game of Chairs" in Season 45's Episode 4522. Grover appears as "Grover Bluejoy" among caricatures of Tyrion Lannister (Martin P. Robinson), Cersei Lannister (Carmen Osbahr), Daenerys Targaryen (Stephanie D'Abruzzo) (and a baby dragon), Melisandre the Red Woman (Leslie Carrara-Rudolph), Ned Stark (Tyler Bunch), Robb Stark (Matt Vogel), and Joffrey Baratheon (Peter Linz).
- The official Twitter account for Sésamo tweeted an image of Cookie Monster as a member of the Night's Watch facing off against two dragon cookies on April 14, 2019, prior to the premiere of Game of Thrones season 8. The caption reads, "Winter has come and Sesame Street knows you need 4 things, Biscuits, hot chocolate, a blanket and... MORE COOKIES!" 
- A t-shirt sold at Sesame Place features Cookie Monster with dragon scales in the style of the direwolf sigil from House Stark with a quote that paraphrases Tyrion Lannister, "I eat cookies and I know things." Cookie Monster tweeted a similar quote on April 28, 2019  (the same night episode 3 of season 8 aired).
- Mark Addy played Robert Baratheon (2011)
- Roger Ashton-Griffiths played Mace Tyrell (2014-2016)
- Sean Bean played Ned Stark (2011)
- Jim Broadbent played Archmaester Ebrose (4 episodes, 2017)
- Gwendoline Christie played Brienne of Tarth (2012-2019)
- Mackenzie Crook played Orell (2013)
- Charles Dance played Tywin Lannister (2011-2015)
- Oliver Ford Davies played Maester Cressen in "The North Remembers" (2012)
- Peter Dinklage played Tyrion Lannister
- Jane Espenson co-wrote the teleplay for "A Golden Crown" (2011)
- Tara Fitzgerald played Selyse Baratheon (2013-2015)
- David Forman served as an assistant stunt coordinator
- Mark Gatiss played Tycho Nestoris (4 episodes, 2012-2017)
- Kit Harington played Jon Snow
- Lena Headey played Cersei Lannister
- Sibel Kekilli played Shae (2011-2014)
- Rose Leslie played Ygritte (2012-2014)
- Patrick Malahide played Balon Greyjoy (4 episodes, 2012-2016)
- Ian McShane played Brother Ray in "The Broken Man" (2016)
- Gary Pollard served as a prosthetic make-up artist
- Jonathan Pryce played the High Sparrow (2015-2016)
- Diana Rigg played Olena Tyrell (2013-2017)
- Thomas Sangster played Jojen Reed (2013-2014)
- Helen Sloan served as an on-set photographer
- John Standing played Jon Arryn in "Winter Is Coming" (2011)
- Yousef Sweid played Ash in "Book of the Stranger" (2016)
- Sophie Turner played Sansa Stark
- Spencer Wilding played a White Walker in "Winter Is Coming" (2011)