President George H.W. Bush (1924-2018) was the 41st President of the United States of America from 1989 to 1993. In 1990, he appeared with his wife, then First Lady Barbara Bush, to introduce the video release of the animated anti-drug television special Cartoon All-Stars to the Rescue, which featured appearances by Baby Kermit, Baby Piggy, and Baby Gonzo.
- The Muppet Babies episode "Happy Birthday, Uncle Piggy" features Baby Piggy and Skeeter interacting with a still photo of George (voiced by Frank Welker) and Barbara Bush at a pretend birthday party. Baby Piggy later gives the cut-out photo to Uncle Statler as a birthday gift. He comments that he's never had a president at his parties.
- In 1994, Bush and his wife Barbara were spoofed in The Muppets Make Puppets! as George and Barbara Brush.