George Lopez is a sitcom starring George Lopez, using his real name as a fictional aircraft parts factory employee and family man.
- In episode 8 of From the Balcony, co-star Constance Marie appears, with the on-screen text identifying her as from The George Lopez Show. Pepe the King Prawn asks her if her TV husband George Lopez is a good kisser. Once assured he isn't there, she complains about the breath on that man, "you know, halitosis?"
- In the season 4 episode "Sk8erboyz," Carmen Lopez comments on her little brother Max's clothes and tells her mother, "You still dress him like he's in elementary school. Dorky shirt, dorky pants. You can't even see his boxers. Why don't you just dress him in a Tickle Me Elmo shirt and send him to his death?"
- Sandra Bullock played Amy (3 episodes, 2002-2003) and executive produced
- Michael Clarke Duncan played Dr. Holland in "George to the Third Power" (2005)
- Lillian Hurst played Mrs. Cardenas in "Who's Your Daddy?" (2002)
- George Lopez played George Lopez and executive produced
- Mario Lopez played Officer Hector Sanchez in "George Can't Let Sleeping Mexicans Lie"
- Eva Longoria played Brooke in "George Vows to Make Some Matri-Money"
- Constance Marie played Angie Lopez
- Cheech Marin played Lalo in "Guess Who's Coming to Dinner, Honey" (2002)
- Rita Moreno played Luisa Diaz in "George Testi-Lies for Benny" (2007)
- Nick Offerman played Randy (2003-2004)
- Lou Diamond Phillips played George Lopez's brother, George Lopez in "George vs. George," and "Would You Like a Drumstick or a Kidney?" (2003)
- Brenda Song played Jennifer in "Token of Unappreciation" (2002)
- Jerry Springer played Wayne in "George is Lie-able for Benny's Unhappiness" and "George Decides to Sta-Local Where It's Familia" (2007)
- Ashley Tisdale played Olivia in "I Only Have Eyes For You" (2003)
- Danny Trejo played Bobby in "George's Extreme Makeover: Holmes Edition" (2005)
- Ming-Na Wen played Professor Lim in "George Enrolls Like That," and "George Keeps Truant to Himself" (2006)
- George Wendt played Ed in "The Simple Life," and "Trouble in Paradise" (2004)