Since 2009, he has been a co-anchor on Good Morning America. In that capacity, he has occasionally interacted with the Muppets, asking Elmo for an autograph in 2010, while in 2014, Mr. Snuffleupagus expressed pleasure at finally meeting "my hero, George Stephanopoulos." They further joked about whether there was a family resemblance.
- In The Muppets episode "A Tail of Two Piggies," ABC network president Lucy Royce states that George Stephanopoulos has lobbied for years to wear a crop top: "Nobody wants to see Greek belly." Piggy later mentions Stephanopoulos as one of the little people (along with Alynda) who are counting on her to show them it's okay to be themselves.