The character was created by writer Nancy Sans, originally as a day player role. Her first episode, in season 18, involved her getting lost on the way to 123 Sesame Street, where Gordon and two directionally-abled science class students were watching the night sky. She made a few more recurring appearances that season, including Episode 2263, 2293, 2309, 2319 and 2337.
When she was introduced as a regular, she worked at Hooper's Store, getting the job in Episode 2358. She has developed friendships with Mike and Savion, and had a romantic relationship with Jesse. She graduated from high school (Class of 1990) at the end of season 21 in Episode 2745 and continued to work at Hooper's Store while figuring out what life path to follow.
In Episode 3397 (Season 27), she revealed that she wished to work in child care and had taken night classes, earning her teaching certificate and working part-time at a day care center. From season 27 to season 29, she ran the day care center located Around the Corner.
In season 30, she began studying to become a veterinarian. In season 32, she opened her own vet clinic in the building that used to serve as a garage in the courtyard. In a game produced for Kinect Sesame Street TV, it is mentioned that Gina instead runs a dog-grooming business called Just Fetching.
Gina's mother appeared off-screen in Episode 2595 (voiced by Camille Bonora), and later onscreen at her daughter's graduation ceremony in Episode 2745. According to Episode 4260, Gina's mother is Italian.
- Although the character was phased out of the show in 2016, her full name (Dr. Gina Jefferson) appears on the window of the "Community Vet Clinic" at Sesame Street at SeaWorld, opened in 2019.
- The script for Episode 2640 refers to a young girl played by Anna Carra as Gina's little sister, however this is not mentioned in the episode as aired. Similarly, the script for Episode 2745 mentions her presence at Gina's graduation, but she is not seen in the aired episode.
- Films and Specials
- Sesame Street, Special
- Sesame Street: 20 and Still Counting
- Big Bird's Birthday or Let Me Eat Cake
- Sesame Street: 25 Wonderful Years
- Elmo Saves Christmas
- Sesame Street Stays Up Late
- The Adventures of Elmo in Grouchland
- The Street We Live On
- Sesame Street's 50th Anniversary Celebration
- Home Videos
- The Best of Ernie and Bert
- Big Bird's Favorite Party Games
- Let's Play School
- Rock & Roll!
- Dance Along!
- Sesame Street Visits the Hospital
- Telling the Truth
- Sesame Street Goes to the Doctor
- What's the Name of That Song?
- Elmo's Potty Time