- In February 2016, Elmo appeared in a web video to help promote the show's daily “Ham4Ham” lottery. Elmo visited the set of Hamilton to sing "The Story of Tonight" with Christopher Jackson (George Washington).
- Miss Piggy told Harry Connick, Jr. on his show in December 2016, that she turned down a role in Hamilton because she refuses to do anything with the word "ham" in it.
- In Muppets Meet the Classics: The Phantom of the Opera, a confused patron of the Opera House complains about the new production of Faust, claiming he wishes to see Hamilton.
- Abby Cadabby performed the song "Satisfied" on the set of Sesame Street in a video posted to Twitter in 2018 by Sesame Street and Hamilton choreographer, Stephanie Klemons. (video)
- A poster in the waiting queue for Oscar's Wacky Taxi at Sesame Place features Oscar the Grouch spoofing the show as "Scramilton".
- Michael Aarons is music coordinator for the show.
- Utkarsh Ambudkar originated the role of Aaron Burr in the show's 2013 workshops.
- Randy Cohen programmed keyboards and synthesizer for the show.
- Daveed Diggs originated the roles of Marquis de Lafayatte and Thomas Jefferson
- Jonathan Dinklage is concertmaster for the show.
- Renée Elise Goldsberry originated the role of Angelica Schuyler.
- James Monroe Iglehart was a replacement as Marquis de Lafayette and Thomas Jefferson (beginning April 14, 2017).
- Christopher Jackson originated the role of George Washington.
- Taran Killam was a replacement as King George III (January 17-April 13, 2017)
- Alex Lacamoire is the musical director, arranger, orchestrator, conductor, and plays keyboards.
- Lin-Manuel Miranda wrote and co-arranged the music, lyrics and book for the play and originated the role of Alexander Hamilton.
- Leslie Odom Jr. originated the role of Aaron Burr on Broadway
- Anja Wood plays cello in the orchestra.