- Together they interviewed Kermit the Frog and Miss Piggy about Studio DC Hosted by Dylan and Cole Sprouse on July 29, 2008.
- On November 13, 2008, when the Muppets took over Today, both sat down with Miss Piggy again.
- On March 19, 2014 Kotb and Gifford interviewed Kermit and Miss Piggy once again.
- On New Year's Eve 2014 she and Gifford co-hosted A Toast to 2014!, on which Miss Piggy also made an appearance.
- And on November 8, 2018, Today aired a pre-recorded segment, that showed Kotb bringing her baby daughter to the set of Sesame Street in order to meet Big Bird, Elmo, Grover, Abby Cadabby and Cookie Monster. Big Bird, Elmo and Abby also appeared live in-studio to talk with the hosts.
On May 29, 2019, Kotb hosted the 50th Anniversary Sesame Workshop Benefit Gala.