Iguana appears in the Elmo the Musical segment, "Iguana the Musical."
Elmo, imagining himself as an iguana, comes across his fellow reptile friend, who teaches him some Spanish words. She then gets a call informing her that today is her grandmother's birthday, but she can't attend because she lives too far away in Mexico. Elmo uses his imagination to send them there and they use a photo on Iguana's phone for reference to find her house; it has a blue door, red roof and yellow mailbox. After some mistaken encounters, they finally reach her grandmother's house, just in time for the celebration.