- Episode 202 of Muppets Tonight features a trailer for the fake film "Co-Dependence Day: CD4," in which a caricature of the aliens seen in ID4 (represented by Meepzorp) enters therapy for the devastation brought down on Earth's major cities.
- Muppets from Space spoofs a scene from ID4 in which Dr. Brackish Okun pressed against a window and telepathically maneuvered by an alien to speak the phrase "release me" to a group of onlookers. In Muppets from Space, Dr. Phil van Neuter is placed in an almost identical position by a group of rats rescuing Gonzo.
- Episode 27 of From the Balcony features the balconism, "Armed FARCES," which describes when a movie plot renders the Army useless when the hero turns out to be an Average Joe. One of their examples is Randy Quaid in Independence Day which Waldorf cites as a great patriotic movie. As Statler rebuts the claim, a UFO casts its shadow over the pair before it blasts their set to pieces, referencing a sequence from the film.
- Harry Connick Jr. played Captain Jimmy Wilder
- Harvey Fierstein played Marty Gilbert
- Jeff Goldblum played David Levinson
- Judd Hirsch played Julius Levinson
- Raphael Sbarge played a commander
- Brent Spiner played Dr. Brackish Okun
- Frank Welker supplied special vocal effects
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