Her favorite food is pizza, and she loves playing MonsterBall (which is kind of like soccer, but for monsters).
She is shown to be in the care of two foster parents, Dalia and Clem. She is also good friends with Elmo. Though not addressed in the videos, the writers suggest that her mother's absence is due to being "away getting treatment for substance abuse."
Karli also starred in videos focusing on substance abuse, debuting on the site in October 2019.