- Appearing in The Muppets episode "Swine Song", Key and Peele explain to Kermit and Piggy that Pache had been assigned to refurbish their show, but it ended with getting Key & Peele cancelled and the pair of them selling oven mitts on Etsy.
- A season 2 "Obama and Luther" sketch references Mitt Romney's remark toward Big Bird in the 2012 President debates. Luther angrily yells, "How you gonna fire Sesame Street?! One of those motherfuckers already lives in a trashcan!"
- In the season 3 episode "Les Mis," substitute teacher Mr. Garvey insults a student's hairdo, calling it "Fraggle Rock hair."
- In the season 3 episode "Sexy Vampires," a zombie extra played by Jordan Peele uses one take of a film to make his zombie make high pitched squeaks. Another zombie extra, played by Keegan-Michael Key, calls them "Beaker sounds."
- Tatyana Ali played Heresa in "Hollywood Sequel Doctor"
- Utkarsh Ambudkar played Friend #2 in "Severed Head Showcase"
- Wayne Brady appears in "Michael Jackson Halloween"
- Ty Burrell played Colonel Muller in "Awesome Hitler Story" and "Parole Officer Puppet"
- Malcolm-Jamal Warner appeared in "Slap-Ass" and "Sex Detective"
- Rebecca Romijn played Pirate Captain in "Y'all Ready for This?"
- Brenda Song played Purple Falcon in "Gangsta Standoff"
- Billy Dee Williams appeared as himself in "Dueling Hats"
- Tyler James Williams played Jaleel White / Steve Urkel in "Slap-Ass: In Recovery"
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