Matthew Santoro (b. 1985) is a YouTuber best known for his top ten and "50 Amazing Facts" videos. In 2015, he interviewed Elmo, Raya, and the Count at the Global Citizen Festival. (YouTube)
He previously collaborated with Vsauce3's Jake Roper on the video "What if Quicksilver Ran Past You?" which featured the Muppets. Although he didn't interact with the Muppets himself, Gonzo and Rizzo (acting as narrators of the video) refer to Santoro multiple times. (YouTube)
Santoro has collaborated with a number of other fellow YouTubers, including Lilly Singh, Rhett and Link, Hank Green, and more. He's also appeared in the film Resident Evil: The Final Chapter (with William Levy).