Henson provided voice narration similar to how he approached projects using the Limbo character -- in other words, going through a series of memories in the subject's head. In this case, the narrator (played by an on-camera actor in framing scenes, but dubbed by Henson) describes to the viewer how Bufferin was able to keep away a headache in order to make way for saving happy thoughts from a family picnic. The man's children are played by John Henson and Cheryl Henson.
The soundtrack was engineered by Raymond Scott, and can be found on the album Manhattan Research, Inc. as well as a shorter demo. The commercial can also be heard on the Rough Trade Shops collection "Electronic 01."