- In the fourth season Farscape episode "Kansas," John Crichton arrives back on Earth in 1985, and hears an audio transmission, which quotes President Reagan's concerns over the situation in Nicaragua. In episode "Revenging Angel", animated Aeryn transforms into Nancy Reagan.
- An altered picture of Kermit the Frog with Ronald Reagan and Mikhail Gorbachev hangs in Kermit's office in The Muppets as well as a picture of Kermit with Ronald and Nancy.
- An Anything Muppet caricature of Nancy appears as President Elmo's "second lady" in the "Elmo the Musical" segment, "President the Musical."
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