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Once in a lifetime.jpg
Written by David Byrne, Brian Eno, Chris Frantz, Jerry Harrison, Tina Weymouth
Date 1980
Source Remain in Light (album)
Publisher Index Music Inc., Bleu Disque Co. Inc., EG Music Ltd.

"Once in a Lifetime" is a Talking Heads song performed by Kermit the Frog in episode 109 of Muppets Tonight.

Kermit did the number to fill in for Giganticus, who was unable to make it for the show. The suit worn by Kermit in the number was made for Giganticus, which parodies the suit Talking Heads band member, David Byrne, wore on stage in the band's concert film Stop Making Sense.