One Flew Over the Cuckoo's Nest began life as a 1962 novel by Ken Kesey, was adapted for the Broadway stage by Dale Wasserman in 1963, and became a feature length film in 1976. All three are set in an Oregon asylum, and the film won five Academy Awards.
- The film was spoofed in a Monsterpiece Theater segment on Sesame Street, where the Number 1 flew over a cuckoo's nest.
- A movie marquee displays the title of the film in a Sesame Street video segment of a father and daughter riding a bus around town. (First: Episode 0926)
- A mail carrier has mail for Nurse Ratched (the cruel asylum nurse in the movie) in Sesame Street episode 3527.
- Edwin Cooper played Frank Scanlon in the 1971 off-Broadway production
- Danny DeVito played Martini in the film
- Anjelica Huston made an uncredited appearance in the film as an extra
- Christopher Lloyd played Taber in the film
- Rex Robbins played Dr. Spivey in the original Broadway production
- Gene Wilder played Billy Bibbit in the original Broadway production