- Oscar the Grouch appeared in the season 5 episode "Fashion." When Fred is diagnosed with grumpiness, Oscar briefly appears in an alley way to encourage him to embrace his inner grump. Matt Vogel puppeteered Oscar for the scene with Paul McGinnis assisting, which was later re-dubbed by Caroll Spinney.
- In the season 1 episode "Baseball", a high-strung couple (Fred and Carrie) attend an outdoor movie screening in a park:
- Carrie: Last time we were here, according to my watch, the movie started at 8:30 on the dot.
- Organizer: Well, if it's not completely dark, then...
- Fred: Just, just for next time, that's all. It's just that last time ran a little bit differently. We were here for The Muppet Movie and Muppets Take Manhattan.
- In "Inside Portlandia," a bonus feature on the season 2 DVD, series co-creator Jonathan Krisel compares Fred and Carrie to Bert and Ernie, even asking rhetorically "what is their sexual preference?"
- Fred Armisen played various characters
- Roseanne Barr played Mrs. Mayor in "The Temp"
- Rachel Bloom played Rachel in "No Thank You"
- Claire Danes played the storyteller coach in "The Storytellers"
- Rachel Dratch played Josefina in "Amore"
- Jeff Goldblum played Adam
- Bill Hader played Birdman in "Blackout"
- Sean Hayes played Sean in "Cops Redesign"
- Jane Lynch played the barbecue planner in "4th of July"
- Kyle MacLachlan played the mayor
- Penny Marshall played Barbara in "Feminist Bookstore's 10th Anniversary"
- Jack McBrayer played the Whole Foods customer in "Cool Wedding"
- Edie McClurg played the mayor's secretary in "Mayor Is Missing"
- Seth Meyers played Chad Koop in "Dead Pets"
- Bobby Moynihan played Robert in "Winter in Portlandia"
- Paul Reubens played the weirdoes' lawyer in "Dead Pets"
- Tim Robbins played Excellency in "Brunch Village"
- Maya Rudolph played Anita in "Bahama Knights"
- Jay Pharoah played Jay-Z in "Ecoterrorists"
- Andy Richter played Larry in "Passenger Rating"
- Andy Samberg played The Mixologist in "Mixologist"
- Paul Simon guest-starred in "You Can Call Me Al"
- Robert Smigel played Jarvis in "Lance is Smart"
- Gwen Stefani guest-starred in "Nina's Birthday"
- George Wendt played George Heely in "Off the Grid"
- Jack White guest-starred in "Winter in Portlandia"
- Olivia Wilde played Brit
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