The series was initially a rebranded version of Sesame Amigos, which consisted of The Furchester Hotel, Bert and Ernie's Great Adventures, and "Cookie's Crumby Pictures," framed by original scenes starring Elmo, Rosita, and Lola and occasional celebrity guests. For Sésamo, the series added an additional, animated segment, "Tu Diciedes."
The third season, consisting of thirteen episodes, features a new set of format segments, including "Cookie Monster's Foodie Truck," the 2017 reboot of "Elmo's World," "Bert and Ernie Fairytales" (imported from Sesamstrasse), animated segments from Sesame Street English, and the original Sésamo series, Pequeñas Aventureras. The season also features new celebrity guest appearances.
A fourth season, made exclusively for TV Azteca debuted on April 27, 2020. The season mostly features dubbed segments from Season 50 of its American counterpart. It also includes segments featuring Basma and Jad from Ahlan Simsim.