In the earliest episodes of the show, Susan was a housewife, having worked as a nurse before she was married. In the latter half of the first season she returned to nursing (in Episode 0096) so that the character might serve as a better role model for young girls in the viewing audience. Among her projects was offering a Measles Vaccination Clinic in Episode 0343. Susan also worked as a mechanic on the street, commonly fixing cars and even the bus when Big Bird went to camp in Episode 1706. During the early seasons, she often sang "One of These Things."
She also headlined her own album Susan Sings Songs from Sesame Street and had minor roles in both Sesame Street movies.
Starting in Season 29, she would appear in only a few episodes per season, in part due to fewer shows being produced. Starting in Season 34, Susan would only appear in one or two episodes per season, excluding Season 42 when she was in four episodes, and the following season, when she didn't appear in any new material. The character was eventually phased out altogether after Season 45, along with several other long-time human characters. However, she did return for Sesame Street's 50th Anniversary Celebration. Their nephew, Chris, continues to be a character on the show.
- Susan states her middle name is Gloria in Episode 0879.
- According to Episode 1444, Gordon and Susan first met in Paw Paw, Michigan (Loretta Long's hometown).
- Christmas Eve on Sesame Street
- Don't Eat the Pictures
- Sesame Street Special
- Sesame Street: 20 and Still Counting
- Big Bird's Birthday or Let Me Eat Cake
- The Street We Live On
- Sesame Street's 50th Anniversary Celebration
- Bedtime Stories & Songs
- Sing Along
- Big Bird's Favorite Party Games
- Sesame Street Visits the Hospital
- Sesame Street's 25th Birthday: A Musical Celebration
- Sesame Street Goes to the Doctor
- What's the Name of That Song?
- Big Bird's Blunder Book (1972)
- Big Bird's Birthday Party (1972)
- I am a Monster (1976)
- The Sesame Street Block Party Coloring Book (1977)
- The Count Counts a Party (1981)
- Everyone Makes Mistakes (1983)
- I'll Miss You, Mr. Hooper (1984)
- Susan and Gordon Adopt a Baby (1985)
- It's Not Fair! (1986)
- Ernie and Bert's New Kitten (1990)
- Grover's Bad Dream (1990)
- Other illustrated appearances