The Andy Griffith Show is a television sitcom starring Andy Griffith as Sheriff Andy Taylor of Mayberry, North Carolina, running on CBS from 1960 until 1968. The show focused on Andy's family (son Opie and Aunt Bee) and friends (especially hyperactive deputy Barney Fife) and assorted mishaps in the small rural town.
- On the April 15, 1965 broadcast of The Jimmy Dean Show, Rowlf referred to Jimmy's rural cousin Calvin as "our answer to Gomer Pyle." By 1965, Gomer had moved from The Andy Griffith Show into his own spin-off (Gomer Pyle, U.S.M.C.) while still having occasional crossover visits from his Mayberry friends.
- On the January 24, 1976 broadcast of Saturday Night Live, Scred appears in a bee costume, expecting to appear in the bee sketch spoofing The Andy Griffith Show. He was told he could play Aunt Bee.
- Jack Burns played Warren Ferguson (1965-1966)
- Jack Dodson played Howard Sprague (1966-1968) and previously played Ed Jenkins in "Lost and Found" (1966)
- Barbara Eden played Ellen Brown in "The Manicurist" (1962)
- Jamie Farr played Silvio in "The Gypsies" (1966)
- Teri Garr played a girl in a red convertible in "The Wedding" (1968)
- Pat Hingle played Fred Gibson in "Wyatt Earp Rides Again" (1966)
- Ron Howard played Opie Taylor
- Arte Johnson played a hotel clerk in "Andy and Barney in the Big City" (1962)
- William Keene played Reverend Tucker (six episodes, 1963-1968)
- Dave Ketchum played Harry Walker in "Floyd's Barbershop" and Fred Michaels in "Goober the Executive" (both 1967)
- Don Knotts played Deputy Barney Fife
- Marc London played Bob Saunders in "The Foster Lady" (1966)
- Howard Morris played Ernest T. Bass (five episodes, 1963-1965), directed eight episodes (1964), voiced a radio announcer in "The Family Visit" (1964) and Leonard Blush in "Barney's Bloodhound" (1964), and played George in "Andy and Helen Have Their Day" (1964)
- Jim Nabors played Gomer Pyle (1962-1964)
- Alan Rafkin directed 22 episodes (1964-1967)
- Don Rickles played Newton Munroe in "The Luck of Newton Munroe" (1965)
- William Schallert played Sam Becker in "Quiet Sam" (1961)
- Hal Smith played Otis Campbell (1960-1966)
- Olan Soule played John Masters (five episodes, 1962-1964)
- Harry Dean Stanton played a proprietor in "Howard's New Life" (1967)
- John Stephenson voiced a radio announcer in "Barney and the Cave Rescue" (1964)