- In the fifth episode, "Cleveland Junior's Cherry Bomb," depicts Cleveland and his son at a baseball game when the giant screen shows the "Kiss Cam." One of the couples making out is Ernie and Bert.
- In the episode, "How Do You Solve a Problem Like Roberta," Cleveland asks his wife, Donna, to hand him a towel with a hood that makes him look like Cookie Monster. Donna gets a blue towel with Cookie Monster eyeballs on it.
- In the episode, "Terry Unmarried", as Cleveland Junior walks to the bathroom, he scats to the Sesame Street cartoon: "Loaf of bread, container of milk, stick of butter...".
- In the episode, "Brown Magic", Cleveland tells Rallo that he is just a prop and that nobody remembers Oscar the Grouch, but they do remember Caroll Spinney.
- In the episode "American Prankster", Donna is taking away Rallo's toys, including a Tickle-me-Elmo doll. Later, Cleveland is seen playing in his bedroom with the same doll, but throws it away.
- In the episode "When a Man (or a Freight Train) Loves His Cookie," as LeVar is singing to his wife, he says "As Cookie Monster so greatly put it, "C is for Cookie and that's good enough for me"
- In the episode "Squirt's Honor," Cleveland Junior sees Rallo on his tablet and says to him, "Muppets huh? You know Kermit's dead? The guy that did his voice died of a bacterial infection. Sore throat one day, next day he croaked."
- Jason Alexander voiced Saul Friedman in "Brotherly Love"
- Edward Asner voiced the Daily Splash Editor in "The Curious Case of Jr. Working at The Stool"
- Hank Azaria voiced Comic Book Guy from The Simpsons in "Hot Cocoa Bang Bang"
- Chris Colfer voiced his Glee character, Kurt Hummel, in "How Do You Solve a Problem Like Roberta?"
- Seth Green voiced his Family Guy character Chris Griffin in various episodes and in "Our Gang." He also voiced Kurt Cobain in "Da Doggone Daddy-Daughter Dinner Dance"
- Jane Lynch voiced Ms. Eck in "Love Rollercoaster"
- Bruno Mars voiced himself in "Menace II Secret Society"
- Questlove voiced himself in "Menace II Secret Society"
- Kevin Michael Richardson voices various characters.
- Craig Robinson voiced LeVar Brown
- Cree Summer voiced the twin in purple at the Stoolbend Rest Home and Guest #1 in "Sex and the Biddy".
- Jennifer Tilly voiced Bonnie Swanson in "Pilot"
- Ashley Tisdale voiced Lacey Stapleton in "The Curious Case of Jr. Working at The Stool"
- Danny Trejo voiced Danny Trejo in "Hot Cocoa Bang Bang" (2011)
- Patrick Warburton voices Joe Swanson in various episodes.
- Kanye West voiced Kenny West
- Will.i.am voiced Bernard. He also voiced himself in "Menace II Secret Society"
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