- In the season two episode "Siskel & Ebert & Jay & Alice," guest-starring Gene Siskel and Roger Ebert as themselves, Sherman is seduced by the two for a position as their co-host on their own TV show. As Ebert thumbs through a photo album, he points out a picture of himself and Siskel from the year they went as Ernie and Bert for Halloween, which was alluded to previously in the episode.
- Kareem Abdul-Jabbar voiced himself in "A Day at the Races and a Night at the Opera"
- Judd Apatow was a writer and producer for the show
- Milton Berle voiced himself in "I Can't Believe It's a Clip Show"
- Nancy Cartwright voiced Margo Sherman
- Christine Cavanaugh voiced Marty Sherman
- Margaret Cho appeared in the pilot episode
- Judith Ivey voiced Eleanor Sherman
- Maurice LaMarche voiced Jeremy Hawke, Shackleford, and various celebrities
- Jon Lovitz voiced Jay Sherman
- Rhea Perlman voiced Ardeth
- Gene Shalit voiced himself in "Siskel & Ebert & Jay & Alice"
- Russi Taylor voiced Penny Tompkins
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