The show spun off the video website and app ellentube, which has featured several appearances by the Sesame Street characters.
- November 9, 2011 - Kermit the Frog appeared to promote The Muppets.
- November 15, 2011 - Amy Adams appeared to promote The Muppets.
- March 11, 2014 - Ricky Gervais appeared to promote Muppets Most Wanted.
- March 19, 2014 - Ty Burrell appeared to promote Muppets Most Wanted.
- October 14, 2015 - Cookie Monster appeared to promote the Sesame Street deck for Ellen's Heads Up! app.
- January 10, 2017 - Oscar the Grouch (Eric Jacobson) appeared to promote Season 47 and their "kindness" initiative.
- In late 2009, Aaron Carter and Karina Smirnoff performed their Dancing with the Stars routine to "The Muppet Show Theme" on the show.
- During an appearance by Jim Parsons, clips were shown from his appearance on Sesame Street. (2011)
- Ellen presented a birthday cake to Lady Gaga that incorporated Kermit the Frog's face (in reference to the artist's infamous outfits).
- In 2012, during Jason Segel's introduction, Ellen refers to him as "The man who brought back the Muppets", referring to the 2011 film.
- In 2014, during a segment about BuzzFeed quizzes, Ellen showed a BuzzFeed quiz which was titled "Which Muppet Are You".