The Silence of the Lambs is a 1991 psychological thriller directed by Jonathan Demme and starring Jodie Foster and Anthony Hopkins, based on the novel of the same name by Thomas Harris.
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- Kermit references the book in One Frog Can Make a Difference: "I just finished this book by Thomas Harris. (Not the Thomas Harris who wrote The Silence of the Lambs. I don't read horror novels. and I didn't see the movie, either. Some of my best friends are sheep.)" Kermit's opinion on horror had changed 21 years later when he expressed a liking for "those Chucky films" in a March 2014 interview with Radio Times.
- A 1998 Toyota commercial animated by Jim Henson's Creature Shop features a goldfish quoting Hannibal Lecter, "I ate his liver with some fava beans and a nice chianti." The line is followed by the same mouth slurping delivered in the movie, used as a sound effect for another fish hurriedly swimming away. A clip was included in The Muppets Present pitch.
- The film was spoofed as one of the "Movie Mania" interstitials which ran on the Odyssey Network.
- In the Farscape episode "Durka Returns," as Crichton looks for Chiana, he calls out to her, "Look, I don't have time to play this game. Durka's gone Hannibal Lecter on us."
- In the Farscape episode "Vitas Mortis," Crichton references one of Hannibal Lecter's quotes, saying, "So, if she wants to rip out your liver, snack on it with a Chianti, she can do that?"
- In the book What's in Oscar's Trash Can?, Oscar's bookcase contains a copy of Silence of the Grouches.
- In a tweet, Uncle Deadly wrote that he lost the part of Hannibal Lecter to Anthony Hopkins.[1]
- In Muppets Most Wanted, Kermit, mistaken for Constantine, is transported by prison staff in a manner that references restraints used for Hannibal Lecter in the film.